- Why Bridges Don’t Sink (practical.engineering)
The essence of a bridge is not just that it goes over something, but that there’s clear space underneath for a river, railway, or road. Maybe this is already obvious to you, but bridges present a unique structural challenge. In a regular road, the forces are transferred directly into the ground. On a bridge, all those forces on the span get concentrated into the piers or abutments on either side. Because of that, bridge substructures are among the strongest engineered systems on the planet. And yet, bridge foundations are built in some of the least ideal places for heavy loading. Rivers and oceans have soft, mucky soils that can’t hold much weight. Plus, obviously, a lot of them are underwater.
- Monoamine oxidase inhibitor (Wikipedia)
Monoamine oxidase inhibitors (MAOIs) are a class of drugs that inhibit the activity of one or both monoamine oxidase enzymes: monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B). They are best known as effective antidepressants, especially for treatment-resistant depression and atypical depression. They are also used to treat panic disorder, social anxiety disorder, Parkinson’s disease, and several other disorders.
