Mississippi (Wikipedia) Mississippi (/ˌmɪsɪˈsɪpi/) is a state in the Southeastern region of the United States, bordered to the north by Tennessee; to the east by Alabama; to the south by the Gulf of Mexico; to the southwest by Louisiana; and to the northwest by Arkansas. Mississippi’s western boundary is largely defined by the Mississippi River. Mississippi is the 32nd largest by area and 35th-most populous of the 50 U.S. states and has the lowest per-capita income in the United States. Jackson is both the state’s capital and largest city. Greater Jackson is the state’s most populous metropolitan area, with a population of 591,978 in 2020.