But since I designed to employ my whole life in the search after so necessary a Science, and since I had fallen in with a path which seems to me such, that if any one follow it he must inevitably reach the end desired, unless he be hindered either by the shortness of life or the want of experiments, I judged that there could be no more effectual provision against these two impediments than if I were faithfully to communicate to the public all the little I might myself have found, and incite men of superior genius to strive to proceed farther, by contributing, each according to his inclination and ability, to the experiments which it would be necessary to make, and also by informing the public of all they might discover, so that, by the last beginning where those before them had left off, and thus connecting the lives and labours of many, we might collectively proceed much farther than each by himself could do.

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René Descartes

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Discourse on the Method (Veitch translation)

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I remarked, moreover, with respect to experiments, that they become always more necessary the more one is advanced in knowledge; for, at the commencement, it is better to make use only of what is spontaneously presented to our senses, and of which we cannot remain ignorant, provided we bestow on it any reflection, however slight, than to concern ourselves about more uncommon and recondite phænomena: the reason of which is, that the more uncommon often only mislead us so long as the causes of the more ordinary are still unknown; and the circumstances upon which they depend are almost always so special and minute as to be highly difficult to detect.

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It is true that the science of Medicine, as it now exists, contains few things whose utility is very remarkable: but without any wish to depreciate it, I am confident that there is no one, even among those whose profession it is, who does not admit that all at present known in it is almost nothing in comparison of what remains to be discovered; and that we could free ourselves from an infinity of maladies of body as well as of mind, and perhaps also even from the debility of age, if we had sufficiently ample knowledge of their causes, and of all the remedies provided for us by Nature.