- Mean Girls is a 2004 American teen comedy film directed by Mark Waters and written by Tina Fey. It stars Lindsay Lohan, Rachel McAdams, Tim Meadows, Ana Gasteyer, Amy Poehler, and Fey. The film follows Cady Heron (Lohan), a naïve teenager who transfers to an American high school after years of homeschooling in Africa. Heron quickly befriends two outcasts (Lizzy Caplan and Daniel Franzese), with the trio forming a plan to exact revenge on Regina George (McAdams), the leader of an envied clique known as the Plastics.