- Dissociative (Wikipedia)
Dissociatives, colloquially dissos, are a subclass of hallucinogens which distort perception of sight and sound and produce feelings of detachment – dissociation – from the environment and/or self. Although many kinds of drugs are capable of such action, dissociatives are unique in that they do so in such a way that they produce hallucinogenic effects, which may include dissociation, a general decrease in sensory experience, hallucinations, dream-like states or anesthesia. Despite most dissociatives’ main mechanism of action being tied to NMDA receptor antagonism, some of these substances, which are nonselective in action and affect the dopamine and/or opioid systems, may be capable of inducing more direct and repeatable euphoria or symptoms which are more akin to the effects of typical “hard drugs” or common drugs of abuse. This is likely why dissociatives are considered to be addictive with a fair to moderate potential for abuse, unlike psychedelics. Despite some dissociatives, such as phencyclidine (PCP) possessing stimulating properties, most dissociatives seem to have a general depressant effect and can produce sedation, respiratory depression, nausea, disorientation, analgesia, anesthesia, ataxia, cognitive and memory impairment as well as amnesia.
- Nancy Pelosi (Wikipedia)
Nancy Patricia Pelosi (/pəˈloʊsi/ pə-LOH-see; née D’Alesandro; born March 26, 1940) is an American politician who served as the 52nd speaker of the United States House of Representatives from 2007 to 2011 and again from 2019 to 2023. A member of the Democratic Party, she was the first woman elected as U.S. House Speaker and the first woman to lead a major political party in either chamber of Congress, leading the House Democrats from 2003 to 2023. A member of the House since 1987, Pelosi currently represents California’s 11th congressional district, which includes most of San Francisco. She is the dean of California’s congressional delegation.