- The Palouse (/pəˈluːs/ pə-LOOSS) is a distinct geographic region of the northwestern United States, encompassing parts of north central Idaho, southeastern Washington, and, by some definitions, parts of northeast Oregon. It is a major agricultural area, primarily producing wheat and legumes. Situated about 160 miles (260 km) north of the Oregon Trail, the region experienced rapid growth in the late 19th century.