- U.S. Route 395 (US 395), also known as U.S. Highway 395, is a north–south United States Numbered Highway that traverses the inland areas of the western states of California, Nevada, Oregon and Washington. It travels for over 1,300 miles (2,100 km) from a junction in the Mojave Desert at Interstate 15 (I-15) in Hesperia to the Canada–U.S. border in Laurier, Washington. Major cities along its route include Carson City and Reno in Nevada; Kennewick and Pasco in Washington’s Tri-Cities region; and Spokane, Washington. US 395 is an auxiliary route of US 95 but never intersects its parent route, which runs further east.