It [Messier 49] is the most luminous member of that [Virgo] cluster and more luminous than any galaxy closer to the Earth.
The name of the third river is the Tigris; it runs along the east side of Ashur. And the fourth river is the Euphrates.
The name of the second river is the Gihon; it winds through the entire land of Cush. Genesis 2:13 NIV