Paleozoic (Wikipedia) The Paleozoic (IPA: /ˌpæli.əˈzoʊ.ɪk,-i.oʊ-, ˌpeɪ-/ PAL-ee-ə-ZOH-ik, -⁠ee-oh-, PAY-; or Palaeozoic) Era is the first of three geological eras of the Phanerozoic Eon. Beginning 538.8 million years ago (Ma), it succeeds the Neoproterozoic (the last era of the Proterozoic Eon) and ends 251.9 Ma at the start of the Mesozoic Era.